Which of the following is NOT a function of the Centers for Medicare and Medicaid Services (CMS)?

The choice indicating that regulation of legislation related to life and safety issues is not a function of the Centers for Medicare and Medicaid Services (CMS) is accurate. CMS primarily focuses on overseeing and administering Medicare and Medicaid programs, along with ensuring compliance with related regulations and policies.

While CMS does play a critical role in determining eligibility criteria, managing agreements with contractors and states, and monitoring contractor performance, its core mission does not encompass the regulation of life and safety issues. That responsibility typically falls under the jurisdiction of other agencies, such as the Centers for Disease Control and Prevention (CDC) or state health departments, which are concerned specifically with public health regulations and safety standards. Thus, the option distinguishing CMS's functions from those related to life and safety regulation is indeed the correct choice.